▎ 摘　　要

In this work, graphene oxide nanosheets (GO) are dual functionalized with Fe3O4 nanoparticles and hydrox-ypropyl cellulose (CLS) for chemo/phototherapy. The TEM, XRD, FTIR, Raman, UV, TG, DLS, and VSM analyses were used to confirm the CLS and Fe3O4 incorporated GO (CLS@mGO) nanobiocomposite structure. Function-alization of magnetite graphene oxide surface by CLS not only improved biocompatibility, colloidal stability, and entrapment efficiency for paclitaxel (PTX) but also accelerated PTX release. Under 808 nm laser light, the CLS@mGO-PTX nanobiocomposite displayed good photothermal features. The CLS@mGO-PTX nano-biocomposite exhibited high photothermal conversion efficiency (47.85%) and photo stability. The notable synergistic chemo/photothermal impacts have also been determined by the in vitro experiments in killing MCF-7 cancer cells. The results of these experiments exhibited that compared to single phototherapy and chemotherapy, chemo/phototherapy could more effectively kill cancer cells by synergetic anticancer impact. Therefore, the CLS@mGO-PTX nanobiocomposite has great potential for chemo/phototherapy.