▎ 摘　　要

Graphene oxide (GO) enwrapped SiO2/TiO2 hollow nanoparticles (GO-HNP) are synthesized by the Stober method and used as a nanocarrier for loading protoporphyrinIX (PpIX). The synthesized nanoparticle has high dispersibility and high uniformity in diameter (ca. 50nm). Furthermore, this nanoparticle shows =808nm laser induced PpIX release properties (photoinduced on-off drug-release system). GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of PTT and PDT exhibits powerful anticancer properties. When cancer cells are treated with GO-HNP-PpIX and irradiated with both visible light and a NIR laser, the cell viability drops dramatically to 2.5%, which is an anticancer effect approximately 13times higher than that obtained in a previous study. Moreover, no significant cell damage has been observed under =808nm laser irradiation. The GO-HNP-PpIX system suggests an external stimuli-responsive efficient anticancer treatment effect toward human breast cancer cells.