▎ 摘　　要

In this study, a simple, sensitive, and high-performance method was employed to extract and preconcentrate ofI a trace amount of sodium barbiturate drug by using mesoporous silica (SBA-15) modified by graphene oxide (GO). TEM, BET, TGA, FE-SEM, EDS, and elemental analysis CHN were used to characterize mesoporous SBA-15 and nanocomposite. Effective parameters in barbiturate extraction such as pH, amount of nanocomposite, eluent type, contacting time, the ionic power of solution, and sample volume were optimized for quantitative determination of the barbiturate. Analytical figures of merit such as accuracy, limit of detection, preconcentration, and enrichment factors were calculated and proved the suitability of our proposed method. The calibration curve shows a linear correlation in the concentration range of 50-2000 ng mL(-1) with the detection limit of 17 ng mL(-1). The relative standard deviation (n=10) was calculated to be 1.39% and the preconcentration factor was achieved 50 using 100 mL of sample.