▎ 摘　　要

The present study was aimed to develop an ultrasensitive technique for electroanalysis of ketamine; a date rape drug. It involved the fabrication of nano-hybrid based electrochemical micro fluidic paper based analytical device (E mu PADs) for electrochemical sensing of ketamine. A paper chip was developed using zeolites nanoflakes and graphene-oxide nanocrystals (Zeo-GO). WAD offers many advantages such as facile approach, economical and potential for commercialization. Nanocrystal modified E mu PAD showed wide linear range 0.001-5 nM/mL and a very low detection limit of 0.001 nM/mL. The developed sensor was tested in real time samples like alcoholic and non-alcoholic drinks and found good correlation (99%). The hyphenation of E mu PAD integrated with nanocrystalline Zeo-GO for detection of ketamine has immense prospective for field-testing platforms. An extensive development could be made for industrial translation of this fabricated device. (C) 2016 Elsevier B.V. All rights reserved.