▎ 摘　　要

A highly sensitive and selective sensor is fabricated based on graphene/titanium dioxide/polyaniline modified glassy carbon electrode (GRP/TiO2/PANI/GCE). It is demonstrated that this sensor can be used for determination of a pharmaceutically important compound aripiprazole (ARP) using square wave voltammetry and cyclic voltammetry (SWV& CV). Scanning electronmicroscope (SEM) was used to investigate the assembly process of the nanocomposite modifier. The electrochemical investigation of ARP at (GRP/TiO2/PANI/GCE) was found to be the function of pH of the supporting electrolyte, and variation in scan rate and concentration. Electro-oxidation of ARP showed irreversible and adsorption-controlled behaviour at GRP/TiO2/PANI/GCE. Charge transfer coefficient and number of electrons and protons involved in the electrode mechanism were calculated. SWV of different concentrations of ARP showed a linear dynamic range from 5 to 40 ng/mL with the detection limit of 0.99 ng/mL. The analytical performance of this sensor has been evaluated for the detection of ARP in pharmaceutical formulation with satisfactory results.