▎ 摘　　要

With first-principles transport simulation, a biosensor device built from a graphene nanoribbon containing a nanopore is designed for DNA sequencing. The four DNA nucleobases can be distinguished from one another by detecting the transverse-currents of this device. To investigate the transport properties and mechanisms of such a device, we examine the motion effects of nucleobases. The analysis of the transmission spectra and frontier orbital energy shows that the transverse-currents variation of the device strongly results from the long-range interaction between nucleobases and the device. This interaction makes transverse-currents ultra-sensitive to the molecule inside the pore. By rotating the nucleotides inside the pore, the transverse-currents of the device vary along with the changes of molecular orientation. Due to the long-range interaction, when nucleobases chain translocates through nanopore of the device, the influences of adjacent nucleobases on transverse-currents cannot be ignored. These novel effects of nucleobases on the transport capacity of the device provide some theoretical guidance for the design of graphene-based nanopore sensor devices.