▎ 摘　　要

Nanomaterials are introduced to drug carriers for enhanced drug loading, improved pH-responsive and, sustained release. Graphene oxide(GO) has gathered significant attention in biomedical applications due to its superior capacity in transporting biomolecules. Authors introduced GO with Calcium alginate(Ca-Alg) to propose a novel drug carrier for gastrointestinal tract with higher encapsulation and sustained release properties. Cipro-floxacin(CIP) has been used as a model drug. Na-Alg and GO concentration, have been optimized based on encapsulation efficiency(EE). The addition of GO improves EE from 75 % to 90 %. An in-vitro drug release study in different environments viz. aqueous, acidic(pH 2.8), and physiological pH(PBS buffer of pH 7.4) to explore the scope of pH-responsive drug delivery. The addition of GO decreases the pore size in Alg-GO, which causes a slower release of drugs in all mediums. In acidic medium, restricted delivery of 60 % drug over 100 h is observed for Alg-GO. In physiological pH, the speedy and gradual release of drugs within 3 h is observed because of the degradation of the polymeric structure.