▎ 摘　　要

In this paper, we propose a rigorous configuration of graphene coated surface plasmon resonance (SPR) sensor with Tungsten Disulfide (WS2) for sensing DNA hybridization. The present configuration is consisted of prism (SF10 glass), Gold (Au), WS2- graphene and sensing medium. We perform the performance parameters of the proposed sensor in terms of sensitivity, detection accuracy and quality factor. Here we report a dramatic enhancement of the overall performance. Addition of graphene layers increase the sensitivity but decrease the other performance parameters. To increase the all performance parameters we add WS2 between metal and graphene layer. Furthermore in this paper, the thickness effect of Gold (Au) is also analyzed. Numerical analysis shows that the variation of SPR angle for mismatched DNA strands is quiet negligible whereas that for complementary DNA strands is considerably countable. Therefore, the proposed biosensor opens a new window towards detection for biomolecular interactions. (C) 2017 Elsevier B.V. All rights reserved.