• 文献标题:   Graphene-based nanomaterials: the promising active agents for antibiotics-independent antibacterial applications
  • 文献类型:   Review
  • 作  者:   XIA MY, XIE Y, YU CH, CHEN GY, LI YH, ZHANG T, PENG Q
  • 作者关键词:   graphene, nanomaterial, antimicrobial agent, drug resistance, infection, microorganism
  • 出版物名称:   JOURNAL OF CONTROLLED RELEASE
  • ISSN:   0168-3659 EI 1873-4995
  • 通讯作者地址:   Sichuan Univ
  • 被引频次:   30
  • DOI:   10.1016/j.jconrel.2019.06.011
  • 出版年:   2019

▎ 摘  要

Graphene-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have shown great potentials in drug delivery and photodynamic/photothermal therapy due to their featured structure and physicochemical properties. In recent years, their antibacterial potentials have also been exploited. The commonly recognized antibacterial mechanisms include sharp edge-mediated cutting effect, oxidative stress and cell entrapment. This antibacterial activity is very important for human health. As we know, infection with the pathogenic bacteria, especially the drug-resistant ones, is a great threat to human lives. Thus, the development of the antibiotics-independent and drug-free antibacterial agents is of great importance and significance. Graphene-based nanomaterials are a kind of such antibacterial agents. An insight into their properties and antibacterial mechanisms is necessary before they are developed into real products. Herein, we provide a comprehensive understanding of the antibacterial application of graphene-based nanomaterials via summarizing their antibacterial activities against some typical microbial species and discussing their unique mechanisms. In addition, the side-effects and problems in using these nanomaterials are also discussed.