▎ 摘　　要

Gold nanostar@reduced graphene oxide (GNS@rGO) nanocomposite was used as a catalyst in a chemiluminescence (CL) reaction. Composites with different sizes of gold nanostars were prepared without any surfactant, and characterized by transmission electron microscopy, UV-visible, FT-IR and Raman spectroscopy. We showed that GNS@rGO can strongly enhance the intensity of luminol-sodiumperiodate CL system and the larger the GNS size, the greater the enhancing effect. This effect results from the unique catalytic action of GNS@rGO, which leads to the acceleration of reactive oxygen species generation. We also found that a remarkable increase in the CL intensity of GNS@rGO-luminol-NaIO4 system occurs in the presence of glutathione (GSH). Based on this observation, a simple and highly sensitive CL probe was developed for detection of GSH. Under the optimum conditions, the calibration curve exhibits a linear range from 1.0 nM to 1.0 mu M for GSH with a detection limit of 0.2 nM. The developed method was applied to the detection of GSH in human plasma samples. (C) 2019 Elsevier B.V. All rights reserved.