• 文献标题:   One-pot fabricating Fe3O4/graphene nanocomposite with excellent biocompatibility and non-toxicity as a negative MR contrast agent
  • 文献类型:   Article
  • 作  者:   ZAN P, YANG CY, SUN H, ZHAO LJ, LV ZW, HE YQ
  • 作者关键词:   fe3o4/graphene nanocomposite, excellent biocompatibility, nontoxicity, negative mr contrast agent
  • 出版物名称:   COLLOIDS SURFACES BBIOINTERFACES
  • ISSN:   0927-7765 EI 1873-4367
  • 通讯作者地址:   Jilin Univ
  • 被引频次:   13
  • DOI:   10.1016/j.colsurfb.2016.04.049
  • 出版年:   2016

▎ 摘  要

We report a facile approach to synthesize water-dispersible nanocomposite with Fe3O4 nanoparticles (NPs) attached to graphene (G), which combines the growth of Fe(3)O(4)NPs and the reduction of graphene oxide (GO) in one single step. The unique hydrophilic surface structure of Fe3O4/G nanocomposite leads to it being colloidally stable, non-cytotoxic, well-dispersible and biocompatible in aqueous solution verified via bio-experiments. In vivo tests also prove that Fe3O4/G nanocomposite, which can be cleared from the body through the metabolic processes, is harmless to the living body. Most importantly, the Fe3O4/G nanocomposite showed T-2 relaxivity (123.04 mM(-1) s(-1)) indicating its potential as a sensitive T-2 contrast agent. (C) 2016 Published by Elsevier B.V.