• 文献标题:   Enhanced neurite outgrowth of PC-12 cells on graphene-monolayer-coated substrates as biomimetic cues
  • 文献类型:   Article, Proceedings Paper
  • 作  者:   LEE JH, SHIN YC, JIN OS, HAN DW, KANG SH, HONG SW, KIM JM
  • 作者关键词:   neuron, graphene, neural engineering, regenerative medicine
  • 出版物名称:   JOURNAL OF THE KOREAN PHYSICAL SOCIETY
  • ISSN:   0374-4884 EI 1976-8524
  • 通讯作者地址:   Pusan Natl Univ
  • 被引频次:   9
  • DOI:   10.3938/jkps.61.1696
  • 出版年:   2012

▎ 摘  要

Neurons are electrically excitable cells that transmit and process information in the nervous system. Recently, the differentiation of human neural stem cells to neurons has been shown to be enhanced on graphene substrates, and differentiated neurons have been shown to be able to still carry electrical signals when stimulated by graphene electrodes. Graphene films grown by using chemical vapor deposition were transferred onto glass coverslips by using the scooping method and were then coated with fetal bovine serum for a neuronal cell culture. The graphene substrates as biomimetic cues have been shown to enhance the neurite outgrowth of PC-12 cells. Our findings suggest that graphene has a unique surface property that can promote neuronal cells, which should open tremendous opportunities in neuroscience, neural engineering and regenerative medicine.