▎ 摘　　要

In this paper, graphene oxide (GO)-chitosan (Cs) nanocapsules [(GO/Cs)(x), x represents the number of GO/Cs bilayers] were prepared via layer-by-layer self-assembly method. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) images show that the (GO/Cs)(x) nanocapsules have a hollow structure with a uniform diameter of 570 nm. The (GO/Cs)(5) nanocapsules were crosslinked with genipin. FESEM and TEM images indicated that the crosslinking process can improve the morphology and stability of the (GO/Cs)(5) nanocapsules in aqueous solution. Furthermore, the drug loading and release behaviors of ibuprofen using (GO/Cs)(5) and G(GO/Cs)(5) nanocapsules as carriers were investigated. The results show the G(GO/Cs)(5) nanocapsules exhibit a higher drug loading ratio and longer release time than the (GO/Cs)(5) nanocapsules.