• 文献标题:   A Highly Sensitive Graphene-based Field Effect Transistor for the Detection of Myoglobin
  • 文献类型:   Article
  • 作  者:   KRSIHNA BV, GANGADHAR A, RAVI S, MOHAN D, PANIGRAHY AK, RAJESWARI VR, PRAKASH MD
  • 作者关键词:   graphene, fet, myoglobin, limit of detection, biosensor, gfet, acute myocardial infarction
  • 出版物名称:   SILICON
  • ISSN:   1876-990X EI 1876-9918
  • 通讯作者地址:  
  • 被引频次:   5
  • DOI:   10.1007/s12633-022-01790-9 EA APR 2022
  • 出版年:   2022

▎ 摘  要

Biomedical applications adapt Nano technology-based transistors as a key component in the biosensors for diagnosing life threatening diseases like Covid-19, Acute myocardial infarction (AMI), etc. The proposed work introduces a new biosensor, based on Graphene Field Effect Transistor (GFET), which is used in the diagnosis of Myoglobin (Mb) in human blood. Graphene-based biosensors are faster, more precise, stronger, and more trustworthy. A GFET is created in this study for the detection of myoglobin biomarker at various low concentrations. Because graphene is sensitive to a variety of biomarker materials, it can be employed as a gate material. When constructed Graphene FET is applied to myoglobin antigens, it has a significant response. The detection level for myoglobin is roughly 30 fg/ml, which is quite high. The electrical behavior of the GFET-based biosensor in detecting myoglobin marker is ideal for Lab-on-Chip platforms and Cardiac Point-of-Care Diagnosis.