▎ 摘　　要

In this work, the targeted modification of carbon paste (CP) by admixing of conductive graphene oxide (GO) and mesoporous natural zeolite with the introduced Ni2+ cations (NiZ), providing electrocatalytic properties, is presented. The performed univariate optimization indicated that 5 % (w/w) of NiZ and GO in the CP is sufficient to ensure a threefold increase in peak current and lower the overpotential of paracetamol (PAR) oxidation, while retaining a low background current and high signal-to-noise ratio. The fabricated CPE/NiZ/GO sensor ensured a linear response in the PAR concentration range from 0.004 to 0.12 mg L-1, advantageously low limit of detection equal to 0.0012 mg L-1 (0.0078 mu M), and high stability of recorded signals (RSD = 3 %). Moreover, the proposed analytical method is characterized by good selectivity and robustness to the presence of interference. The use-fulness of the CPE/NiZ/GO was verified by the determination of PAR in pharmaceuticals, human urine and serum, delivering acceptable results.