• 文献标题:   Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy
  • 文献类型:   Article
  • 作  者:   XING RR, JIAO TF, LIU YM, MA K, ZOU QL, MA GH, YAN XH
  • 作者关键词:   protein, graphene oxide, singlet oxygen generation, coassembly, photodynamic therapy
  • 出版物名称:   POLYMERS
  • ISSN:   2073-4360
  • 通讯作者地址:   Yanshan Univ
  • 被引频次:   89
  • DOI:   10.3390/polym8050181
  • 出版年:   2016

▎ 摘  要

The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6-BSA-GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6-GO), Ce6-BSA-GO nanohybrids showed enhanced cellular uptake and in vitro release of Ce6, leading to an improved PDT efficiency. These results indicate that the smart photosensitizer delivery system constructed by co-assembly of GO and albumin is promising to improve the stability, biocompatibility, and efficiency of PDT.