• 文献标题:   Modulating A beta(33-42) Peptide Assembly by Graphene Oxide
  • 文献类型:   Article
  • 作  者:   LI Q, LIU L, ZHANG S, XU M, WANG XQ, WANG C, BESENBACHER F, DONG MD
  • 作者关键词:   amyloid peptide, assembly, graphene oxide, modulated structure
  • 出版物名称:   CHEMISTRYA EUROPEAN JOURNAL
  • ISSN:   0947-6539 EI 1521-3765
  • 通讯作者地址:   Aarhus Univ
  • 被引频次:   40
  • DOI:   10.1002/chem.201402022
  • 出版年:   2014

▎ 摘  要

Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (A beta(33-42)). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene-based materials to inhibit amyloidosis.