• 文献标题:   Nano-Graphene Oxide Based Multichannel Sensor Arrays towards Sensing of Protein Mixtures
  • 文献类型:   Article
  • 作  者:   BEHERA P, DE M
  • 作者关键词:   arraybased sensing, fret efficiency, linear discriminant analysis lda, nanographene oxide, protein sensing
  • 出版物名称:   CHEMISTRYAN ASIAN JOURNAL
  • ISSN:   1861-4728 EI 1861-471X
  • 通讯作者地址:   Indian Inst Sci
  • 被引频次:   6
  • DOI:   10.1002/asia.201801756
  • 出版年:   2019

▎ 摘  要

Optical array-based sensors are attractive candidates for the detection of various bio-analytes due to their convenient fabrication and measurements. For array-based sensors, multichannel arrays are more advantageous and used frequently in many electronic sensors. But most reported optically array based sensors are constructed on a single channel array. This difficulty is mainly instigated from the overlap in optical responses. In this report we have used nano-graphene oxide (nGO) and suitable fluorophores as sensor elements to construct a multichannel sensor array for the detection of protein analytes. By using the optimized multichannel array we are able to detect different proteins and mixtures of proteins with 100 % classification accuracy at sub-nanomolar concentration. This modified method expedites the sensing analysis as well as minimizes the use of both analyte and sensor elements in array-based protein sensing. We have also used this system for the single channel array-based sensing to compare the sensitivity and the efficacy of these two systems for other applications. This work demonstrated an intrinsic trade-off associated with these two methods which may be necessary to balance for array-based analyte detections.