• 文献标题:   Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs
  • 文献类型:   Article
  • 作  者:   GU XH, CAO R, LI F, LI Y, JIA HG, YU H
  • 作者关键词:  
  • 出版物名称:   JOURNAL OF CHEMISTRY
  • ISSN:   2090-9063 EI 2090-9071
  • 通讯作者地址:   Qiqihar Univ
  • 被引频次:   1
  • DOI:   10.1155/2018/6325870
  • 出版年:   2018

▎ 摘  要

In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.