▎ 摘　　要

A sensitive electrochemical sensor based on in situ modification of graphite electrode via graphene nanosheets (GNs) was developed as a green method for prazosin hydrochloride (PRA) analyses. In this study, GNs were electrochemically synthesized on the surface of graphite electrode via in situ approach and used for the analyses. The proposed sensor showed several advantages such as high sensitivity, low LOD, and excellent repeatability. The oxidation peak current at the optimum analytical conditions using a GNs/graphite electrode at pH6.0 was linearly dependent on PRA concentration in the range of 0.09-100 mu M. A LOD of 0.02 mu M and RSD of 3.8% for 10 mu M solution of PRA with a great recovery were obtained.