• 文献标题:   Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease
  • 文献类型:   Article
  • 作  者:   WANG KX, WANG LF, CHEN L, PENG CW, LUO BJ, MO JX, CHEN W
  • 作者关键词:   alzheimer #8217, s disease, betaamyloid protein, oxidative stres, neuroprotection, apoptosi, cognition
  • 出版物名称:   DRUG DELIVERY
  • ISSN:   1071-7544 EI 1521-0464
  • 通讯作者地址:  
  • 被引频次:   18
  • DOI:   10.1080/10717544.2021.1895909
  • 出版年:   2021

▎ 摘  要

Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive and memory-related impairment. However, current therapeutic treatments have not proved sufficiently effective, mainly due to the complicated pathogenesis of the disease. In this study, a nano-formulation of graphene oxide (GO) loaded with dauricine (Dau) was investigated in terms of the combined anti-inflammatory and anti-oxidative stress effects of Dau and the inhibition of misfolding and aggregation of the amyloid-beta (A beta) protein by GO. Both in vivo and in vitro models were induced using A beta(1-42), and the formulation was administered nasally in mice. The results showed that GO loaded with Dau greatly reduced oxidative stress through increasing superoxide dismutase levels and decreasing reactive oxygen species and malondialdehyde levels in vitro; it also alleviated the cognitive memory deficits and brain glial cell activation in mice with A beta(1-42)-induced AD. This proved that GO loaded with Dau could protect against A beta(1-42)-induced oxidative damage and apoptosis in both in vitro and in vivo AD models; therefore, GO loaded with Dau has the potential to be an effective and agent for the rapid treatment of AD.