▎ 摘　　要

This work presents a sensitive voltammetric method for determination of curcumin by using a electrochemically reduced graphene oxide (ERGO) modified glass carbon electrode (GCE) in 100 mM KCl-10 mM sodium phosphate buffer solution (pH 7.40), The electrochemical behaviors of curcumin at ERGO/GCE were investigated by cyclic voltammetry, suggesting that the ERGO/GCE. exhibits excellent electrocatalytic activity towards curcumin, compared with bare GCE and GO/GCE electrodes. The electrochemical reaction mechanisms of curcumin, demethoxycurcumin and bisdemethoxycurcumin at the ERGO/GCE were also investigated and discussed systematically. Under physiological condition, the modified electrode showed linear voltammetric response from 0.2 mu M to 60.0 mu M for curcumin, with the detection limit of 0.1 mu m. This work demonstrates that the graphene-modified electrode is a promising strategy for electrochemical determination of biological important phenolic compounds.