▎ 摘　　要

A sensitive electrochemical sensor using graphene self-assembled sodium dodecyl sulfate (SDS) as a composite membrane modified carbon paste electrode was developed for the detection of metronidazole (MNZ) using voltammetry. And the electrochemical properties of the composite membranes were studied by electrochemical impedance spectroscopy and chronocoulometry. At the optimum conditions, the concentration of MNZ was determined using oxidation peak by differential pulse stripping voltammetry (DPSV) in the linear range of 0.08 to 200 mu M with a detection limit of 8.5 nM. The high sensitivity, wider linear range, good reproducibility and the minimal surface fouling made the modified electrode suitable for determining MNZ concentrations in biological samples and tablets. Good recovery results were obtained.