▎ 摘　　要

A simple, rapid and sensitive voltammetric sensor has been fabricated for the determination of histamine (HTM); a neurotransmitter. The graphene nanoribbons were prepared by chemical method and silver nanoparticles (AgNPs) were prepared by the reduction of silver nitrate. The composite of graphene nanoribbons (GNRs) and AgNPs was drop casted on the surface of edge plane of pyrolytic graphite (EPPG) and the GNRs-AgNP exhibited superior catalytic activity towards the oxidation of HTM. To characterize the modified surface film X-ray diffraction, Energy dispersive X-ray analysis, Raman Spectroscopy, Field Emission Scanning Electron Microscopy, Electrochemical Impedance Spectroscopy and cyclic voltammetry have been used. The square wave voltammetry has been used for the quantitative analysis of HTM and the GNRs-AgNP modified sensor demonstrated a linear calibration plots in the concentration range of 1-50 and 60 to 500 mu M with sensitivity 0.158 and 0.083 mu A/mu M and the limit of the detection was found to be 0.049 mu M. The GNRs-AgNPs sensor was highly selective in the presence of common interfering compounds present in biological fluids. The good recoveries (>99%) were found in blood plasma samples. The determination of HTM was carried out in red wine by using standard addition method and the results were validated by using HPLC. The proposed sensor can be effectively applied for the determination of HTM in real samples. (C) 2018 Elsevier B.V. All rights reserved.