▎ 摘　　要

In this study,a simple one-pot method was used to prepare a multifunctional platform for synergistic chemo-and photothermal therapy,,which is composed of zeolitic imidazolate framework-8 (ZIF-8) as drug nanocarriers and the embedded graphene quantum dots (GQDs) as local photothermal seeds.The structure,drug release behavior,photothermal effect,and synergistic therapeutic efficiency of the ZIF-8/GQD nanoparticles were systematically investigated.Using doxorubicin (DOX) as a model anticancer drug,the results showed that monodisperse ZIF-8/GQD nanoparticles with a particle size of 50-100 nm could encapsulate DOX during the synthesis procedure and trigger DOX release under acidic conditions.The DOX-loaded ZIF-8/GQD nanoparticles could efficiently convert near-infrared (NIR) irradiation into heat and thereby increase the temperature.More importantly,with breast cancer 4T1 cells as a model cellular system,the results indicated that the combined chemo-and photothermal therapy with DOX-ZIF-8/GQD nanoparticles exhibited a significant synergistic effect,resulting in a higher efficacy to kill cancer cells compared with chemotherapy and photothermal therapy alone.Hence,ZIF-8/GQD nanoparticles would be promising as versatile nanocarriers for synergistic cancer therapy.