• 文献标题:   Facile Electrochemically Reduced Graphene oxide-Multi-walled Carbon Nanotube Nanocomposite as Sensitive Probe for in-vitro Determination of Nitrofurantoin in Biological Fluids
  • 文献类型:   Article
  • 作  者:   KUMMARI S, KUMAR VS, GOBI KV
  • 作者关键词:   ergocnt composite, nitrofurantoin, electrocatalysi, amperometry, serum analysi
  • 出版物名称:   ELECTROANALYSIS
  • ISSN:   1040-0397 EI 1521-4109
  • 通讯作者地址:   Natl Inst Technol Warangal
  • 被引频次:   0
  • DOI:   10.1002/elan.202060157 EA OCT 2020
  • 出版年:   2020

▎ 摘  要

In this work, electrochemically reduced graphene oxide-carbon nanotube (multi-walled) nanocomposite modified glassy carbon electrode (ErGO-CNT/GCE) has been investigated for direct electrochemical determination of nitrofurantoin (NFT), which is the prime drug used in the treatment of urinary tract infection. Surface of ErGO-CNT/GCE has shown leafy flake-like layers on the nanowire bed of CNTs, promising porous surface structure with enhanced surface area. ErGO-CNT/GCE showed high peak current along with low overpotential in sensing NFT. In differential pulse voltammetry studies, the low detection limit is 20 nM. Steady state current - time analyses carried out in buffer and serum samples resulted a low-detection-limit of 1.87 nM with the analysis time of mere 5 s. Practical application of the fabricated sensor for NFT determination in serum samples has been demonstrated.