▎ 摘　　要

Recently, biological materials have attracted more and more attentions on preparing the surface-enhanced Raman spectroscopy (SERS) substrate with the conspicuous SERS performance. Herein, we demonstrate a simply facile and inexpensive approach to fabricate a novel natural SERS substrate based on graphene oxide-Ag nanoparticles-Mytilus coruscus (GO-AgNPs-M.c.). The surface-enhanced resonance Raman spectroscopy (SERRS) signals of the Rhodamine 6G (R6G) on the GO-AgNPs-M.c. hybrids exhibit the much better SERRS performances in terms of the sensitivity, the signal reproducibility and the antioxidant stability than that on the AgNPs-M.c. one. The well electric field enhancement contribution is likewise confirmed in theory via the COMSOL software. Moreover, the successful detection of trace malachite green (MG) and methylene blue (MB) indicates the well feasibility for multi-molecules detection on the GO-AgNPs-M.c. hybrids. Thus, this inexpensive and high-efficiency natural SERS substrate have great potential for the considerable biochemical SERS applications and broaden the way for preparing multiple SERS platforms derived from other natural materials. (C) 2018 Elsevier B.V. All rights reserved.