• 文献标题:   Achievements of Graphene and Its Derivatives Materials on Electrochemical Drug Assays and Drug-DNA Interactions
  • 文献类型:   Review, Early Access
  • 作  者:   IMANZADEH H, BAKIRHAN NK, KURALAY F, AMIRI M, OZKAN SA
  • 作者关键词:   graphene, sensor, direct electrochemistry, drug, drugdna interaction
  • 出版物名称:   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
  • ISSN:   1040-8347 EI 1547-6510
  • 通讯作者地址:  
  • 被引频次:   1
  • DOI:   10.1080/10408347.2021.2018568 EA DEC 2021
  • 出版年:   2021

▎ 摘  要

Graphene, emerging as a true two-dimensional (2D) material, has attracted increasing attention due to its unique physical and electrochemical properties such as high surface area, excellent conductivity, high mechanical strength, and ease of functionalization and mass production. The entire scientific community recognizes the significance and potential impact of graphene. Electrochemical detection strategies have advantages such as being simple, fast, and low-cost. The use of graphene as an excellent interface for electrode modification provides a promising way to construct more sensitive and stable electrochemical (bio)sensors. The review presents sensors based on graphene and its derivatives for electrochemical drug assays from pharmaceutical dosage forms and biological samples. Future perspectives in this rapidly developing field are also discussed. In addition, the interaction of several important anticancer drug molecules with deoxyribonucleic acid (DNA) that was immobilized onto graphene-modified electrodes has been detailed in terms of dosage regulation and utility purposes.