▎ 摘　　要

Nanocomposites and nanomaterials have frequently useful advantages for drug delivery applications because of their excellent potential in cancer therapy. This study development of nanocomposites from graphene/N-phthaloylchitosan -graft- poly(methylmethacrylate-block-(poly ethylenglycol methacrylate -random-dimethylaminoethyl methacrylate), CS-g-P(MMA-b-(PEGMA-ran-DMAEMA), via reversible addition fragmentation chain transfer polymerization. The structure of the copolymer and nanocomposite were investigated by FT-IR and (HNMR)-H-1. The nanocomposites properties of GO/ CS-g-P(MMA-b-(PEGMA-ran-DMAEMA) were investigated by scanning electron microscopy (FE-SEM), dynamic light scattering, ultraviolet-visible (UV-Vis) spectroscopies, and thermogravimetry measurements. We developed a biodegradable GO nanocomposites to overcome limitations of doxorubicin (DOX)-loading. The drug loading efficiency of GO/nanocomposites for DOX was high, and 81% efficiency was obtained. Release behavior of DOX from the nanocomposites showed that the rate of DOX release is controlled by pH values.