▎ 摘　　要

Highly sensitive recognition of important chiral bioactive substances in complex biological fluids is a great challenge. An efficient chiral discrimination system for amino propanol enantiomers is reported based on R-mandelic acid calix[4] arene (FC4D) clicked graphene. Notably, taking advantages of both the functional calixarene and graphene, the proposed FC4D-G demonstrates extremely high sensitivity and selectivity toward the recognition of amino propanol enantiomers, with a detection limit at the nM level in a serum sample. More important, a visible macroscopic chirality-responsive wettability variation was also realized in this study.