▎ 摘　　要

A novel type of zwitterionic fluorescent nanoparticles (ZFNPs) containing polysulfobetaine groups, the boron dipyrromethane (BODIPY) fluorophore and graphene oxide plates is prepared for the detection of tumor cells in response to the intra- and extracellular stimuli. The fluorescence intensities of the ZFNPs are highly influenced by temperature and pH.