• 文献标题:   Synthesis of a novel thermo/pH sensitive nanogel based on salep modified graphene oxide for drug release
  • 文献类型:   Article
  • 作  者:   BARDAJEE GR, HOOSHYAR Z, FARSI M, MOBINI A, SANG G
  • 作者关键词:   nanogel, salep, graphene oxide, drug release
  • 出版物名称:   MATERIALS SCIENCE ENGINEERING CMATERIALS FOR BIOLOGICAL APPLICATIONS
  • ISSN:   0928-4931 EI 1873-0191
  • 通讯作者地址:   Payame Noor Univ
  • 被引频次:   18
  • DOI:   10.1016/j.msec.2016.11.109
  • 出版年:   2017

▎ 摘  要

Nanogels (NGs) are three-dimensional water soluble cross-linked hydrogel materials in the nanoscale size range with a high loading capacity for guest molecules and act as drug carrier systems. In the present work, a new type of thermo/pH sensitive NG comprising salep modified graphene oxide (SMGO) with branched N-isopropylacrylamide (NIPAM) and acrylic acid (AA) was prepared. The SMGO/P(NIPAM-co-AA) NGs exhibited nanoporous structure and spherical particles with diameters about 82 rim as characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). The samples were also characterized by Fourier transform infrared spectroscopy (FT-IR) and thermo gravimetric analysis (TGA) to further confirm about the formation of NGs. Doxorubicin (DOX) loaded SMGO/P(NIPAM-co-AA) NGs showed thermo/pH dependent releasing behavior: slow drug release at neutral pH and lower temperature but increased significantly in acidic pH and higher temperature, without any burst release. In addition, the NGs exhibited no effect on the cell viability in the tested concentration range up to 410 mu g/mL and drug release systems enhanced toxicity to HeLa cells when compared to the equivalent dose of the free drug. Overall, our results put forth NGs as potential candidates in the development of a new nanocarrier for anti-cancer drug delivery. (C) 2016 Published by Elsevier B.V.