▎ 摘　　要

Conductive polymeric nanocomposites have made significant contributions in nerve regeneration. To this aim, the best results are obtained by using nerve guidance conduits (NGCs) with conductive, bio-compatible, biodegradable tubes as well as special topographical features. In this study, biodegradable, conductive, solvent-free polyurethane/PEGylated graphene oxide (PU/PEG-GO) composites were synthesized and successfully 3D printed into flexible nerve conduits with different precise geometries, such as hollow, porous, and grooved tubes, using stereolithography. The composite containing 5% PEG-GO showed the highest tensile stress (3.51 +/- 0.54 MPa), tensile strain at break (similar to 170%), and conductivity (1.1 x 10(-3 )S/cm) with the lowest contact angle of 72 degrees attributing to the strong interfacial interactions between PEG-GO nanosheets and the PU matrix. Moreover, the PU/PEG-GO 5% exhibited higher compression strength compared with pure PU and showed appropriate enzymatic degradation after 6 weeks, which is expected to last sufficiently for an efficient nerve regeneration. Altogether the 3D-printed, conductive, biodegradable, and flexible PU/PEG-GO 5% conduit with precise geometry has potential as NGCs for peripheral nerve regeneration.