• 文献标题:   PLA graphene nanoplatelets nanocomposites: Physical properties and release kinetics of an antimicrobial agent
  • 文献类型:   Article
  • 作  者:   SCAFFARO R, BOTTA L, MAIO A, GALLO G
  • 作者关键词:   nanocomposite, graphene nanoplatelets gnp, poly lactic acid pla, mechanical propertie, antimicrobial activity, drug release
  • 出版物名称:   COMPOSITES PART BENGINEERING
  • ISSN:   1359-8368 EI 1879-1069
  • 通讯作者地址:   Univ Palermo
  • 被引频次:   47
  • DOI:   10.1016/j.compositesb.2016.10.058
  • 出版年:   2017

▎ 摘  要

Graphene nanoplatelets (GnP) as filler and ciprofloxacin (CFX) as biocide were incorporated via melt compounding into poly(lactic acid) (PLA) to obtain biopolymer-based nanocomposites with antimicrobial properties. GnP were added with the aim of improving the mechanical properties of the antimicrobial system and tuning the drug release. The obtained systems were mechanically characterized in tensile mode by quasi-static and dynamic mechanical tests. Furthermore, rheological measurements were performed. The morphology of the samples was analyzed through scanning electron microscopy (SEM). Moreover, a mathematical model, i.e. power law model, was used to fit the release data in order to investigate the release mechanism. The results showed that the obtained nanocomposite systems exhibit antimicrobial activity. The incorporation of GnP increased the stiffness of the matrix and allowed to reduce the burst release effect. (C) 2016 Elsevier Ltd. All rights reserved.