▎ 摘　　要

The biocompatibility improvement of graphene oxide is crucial for biomedical applications. Herein, we propose to prepare carboxylated graphene oxide (GeneO-COOH) with glutamic acid (Glu) at different pH values. The complexes (GemeO-COOH/Glu) are characterized by FT-IR, XRD, TG, and Zeta potential. The results show that the complexes have close relation with pH value due to the acid-responsive Glu. It is demonstrated that GeneO-COOH complexes with Glu via amidation reaction in the basic domain. The blood compatibility of GeneO-COOH/Glu complexes is evaluated by hemolysis and recalcification test. The results show that the plasma recalcification time is prolonged greatly in the whole blood, and the hemolysis rates are less than 5 %. In a word, GeneO-COOH/Glu complexes are blood compatible at low concentration, which is potential for producing blood-contacting materials.