• 文献标题:   Polymerized graphene oxide/MnCe0.5Fe1.5O4 nanoferrofluid as a T-2- and T-2*-weighted contrast agent for magnetic resonance imaging
  • 文献类型:   Article
  • 作  者:   TORKASHVAND N, SARLAK N
  • 作者关键词:   mnce0.5fe1.5o4 nanocomposite, hela cell line, magnetic resonance imaging, contrast agent, t2weighted imaging
  • 出版物名称:   COLLOIDS SURFACES BBIOINTERFACES
  • ISSN:   0927-7765 EI 1873-4367
  • 通讯作者地址:   Lorestan Univ
  • 被引频次:   1
  • DOI:   10.1016/j.colsurfb.2019.110555
  • 出版年:   2020

▎ 摘  要

In this study synthesis of graphene oxide-poly citric acid/MnCe0.5Fe1.5O4 nanoferrofluid with a simple method and its ability for enhancing the contrast of magnetic resonance images was reported. The co-precipitation method has been used for the production of MnCe0.5Fe1.5O4 nanoparticles with a size distribution of 25-40 nm, which has shown a very good superparamagnetic property with saturation magnetization (M-s) 53.6 emu g(-1). Graphene oxide (GO) was prepared by a modified Hummers method and polymerized with citric acid to produce GO-PCA. The nanoparticles were loaded on the GO-PCA surface to produce nanoferrofluid that showed excellent colloidal stability, extra dispersibility, and good magnetic properties with M-s equal to 47.8 emu g(-1). This nanoferrofluid has an increased effect on the contrast of T-2 and T-2(*)-weighted images, with the values 109.15 and 180.23 mM(-1) s(-1) for r(2) and r(2)(*), respectively at 3.0 T. The cellular uptake evaluation revealed adequate uptake for HeLa cell lines.