• 文献标题:   Assessment of the toxic potential of graphene family nanomaterials
  • 文献类型:   Review
  • 作  者:   GUO XQ, MEI N
  • 作者关键词:   functionalization, genotoxicity, graphene, graphene oxide, reduced graphene oxide, toxicity
  • 出版物名称:   JOURNAL OF FOOD DRUG ANALYSIS
  • ISSN:   1021-9498
  • 通讯作者地址:   Natl Ctr Toxicol Res
  • 被引频次:   176
  • DOI:   10.1016/j.jfda.2014.01.009
  • 出版年:   2014

▎ 摘  要

Graphene, a single-atom-thick carbon nanosheet, has attracted great interest as a promising nanomaterial for a variety of bioapplications because of its extraordinary properties. However, the potential for widespread human exposure raises safety concerns about graphene and its derivatives, referred to as graphene-family nanomaterials. This review summarizes recent findings on the toxicological effects and the potential toxicity mechanisms of graphene-family nanomaterials in bacteria, mammalian cells, and animal models. Graphene, graphene oxide, and reduced graphene oxide elicit toxic effects both in vitro and in vivo, whereas surface modifications can significantly reduce their toxic interactions with living systems. Standardization of terminology and the fabrication methods of graphene-family nanomaterials are warranted for further investigations designed to decrease their adverse effects and explore their biomedical applications. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.