• 文献标题:   Design and fabrication of new anticancer sensor for monitoring of daunorubicin using 1-methyl-3-octylimidazolinium chloride and tin oxide/ nitrogen-doped graphene quantum dot nanocomposite electrochemical sensor
  • 文献类型:   Article
  • 作  者:   ZARE N, KARIMIMALEH H, MOGHADDAM MS
  • 作者关键词:   daunorubicin sensing, anticancer drug sensing, 1methyl3octylimidazolinium chloride, nitrogen doped graphene quantum
  • 出版物名称:   ENVIRONMENTAL RESEARCH
  • ISSN:   0013-9351 EI 1096-0953
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1016/j.envres.2022.114114 EA SEP 2022
  • 出版年:   2022

▎ 摘  要

In this study, a novel tin oxide/nitrogen-doped graphene quantum dot nanocomposite (SnO2-NDGQD) and 1-methyl-3-octylimidazolinium chloride (1M3OICl) ionic liquid amplified carbon paste electrode (CPE) was fabricated as an efficient and fast-response sensor to determine daunorubicin, an anticancer drug. The electro-chemical characteristics of daunorubicin at the surface of the 1M3OICl/SnO2-NDGQD/CPE was explored via various voltammetric methods. The high-resolution transmission electron microscope (HR-TEM) images were recorded to examine the morphological structure of the as-synthesized nanocomposites. The 1M3OICl/SnO2- NDGQD/CPE offered a wide linear concentration of 0.001-280.0 mu M with a low detection limit of 0.40 nM at the optimized experimental conditions using square wave voltammetric (SWV) method. In a nutshell, the developed electrode illustrated outstanding selectivity in the presence of interfering agents and long-term stability. The1-M3OICl/SnO2-NDGQD/CPE was used as new and powerful analytical tool for determination of daunorubicin in real samples with recovery range 98.75%-104.8%.