▎ 摘　　要

Zinc tetra morpholine porphyrin (complex 2), and its quaternized derivative (complex 3) were synthesized and conjugated to folic acid decorated nitrogen doped graphene quantum dots (FA-NGQDs) through it - it stacking to study their photodynamic therapy (PDT) efficacy. Photophysiochemical properties of complexes 2, 3, and their conjugates (2-FA-NGQDs, 3-FA-NGQDs) were studied. It was found that complex 3 had higher CP Delta of 0.56 compared to complex 2 with CP Delta of 0.24, and respective composites: 3-FA-NGQDs had higher CP Delta compared to 2FA-NGQDs. The PDT studies were conducted for nanoparticles (FA-NGQDs), complexes (2, 3), and respective composites (2-FA-NGQDs, and 3-FA-NGQDs) using MCF-7 breast cancer cell. Dark toxicity of all compounds was above 90% which is negligible. At a highest concentration of 40 mu g/mL, 3-FA-NGQDs gave the lowest cell viability of 28% compared to all other conjugates and porphyrins alone.