▎ 摘　　要

In this study, Ag/MnO2@RGO ternary nanocomposite based electrochemical sensor was found to be the best for electrochemical detection of acetaminophen (ACTP). In which, reduced graphene oxide (RGO) sheets decorated with MnO2 nanoclusters and silver nanoparticles (Ag NPs) by in situ growth of MnO2 on graphene oxide (GO) sheets followed by co-reduction of Ag+ and GO. The Ag/MnO2@RGO ternary nanocomposite possesses tremendous superiority in the ACTP sensing is mainly due to the large surface area and numerous electroactive sites. The structural and morphological characteristics of the assynthesized nanomaterial were examined by XRD, FTIR, FE-SEM, HR-TEM, EDX. The electrochemical characteristics and catalytic behavior of the fabricated Ag/MnO2@RGO ternary nanocomposite modified screen-printed carbon electrode for the determination of ACTP were demonstrated using electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry. The results establish that the developed ACTP sensor exhibit a low detection limit of 0.0122 mu M, the excellent linear response of 0.02-1810 mu M with a good sensitivity of 4.144 mu A mu M-1 cm(-2). The practicability of the sensor was investigated in the real sample of acetaminophen tablet and human urine sample.