• 文献标题:   A graphene oxide-copper nanocomposite for the regeneration of the dentin-pulp complex: An odontogenic and neurovascularization-inducing material
  • 文献类型:   Article
  • 作  者:   LI WP, MAO MY, HU N, WANG J, HUANG J, ZHANG WJ, GU SS
  • 作者关键词:   dentinpulp complex regeneration, graphene oxidecopper nanocomposite, dental pulp stem cell, odontogenesi, neurovascularization
  • 出版物名称:   CHEMICAL ENGINEERING JOURNAL
  • ISSN:   1385-8947 EI 1873-3212
  • 通讯作者地址:  
  • 被引频次:   5
  • DOI:   10.1016/j.cej.2021.129299 EA MAR 2021
  • 出版年:   2021

▎ 摘  要

Dentin-pulp complex tissue engineering is a promising novel therapy in endodontics. Materials currently used in regenerative endodontics, e.g., calcium hydroxide and mineral trioxide aggregate, do not ensure full regeneration of the dentin-pulp complex, especially in terms of neurovascular induction. In this study, we fabricated a water-soluble graphene oxide-copper nanocomposite (GO-Cu) and investigated its odontogenic and neurovascularization-inducing abilities by means of dental pulp stem cells (DPSCs). Low-dose (