• 文献标题:   Application of electrocatalytic effects of a newly synthesized monomer and graphene quantum dots to modify glassy carbon microelectrode as a sensor for determination of riluzole
  • 文献类型:   Article
  • 作  者:   HASANPOUR F, FOULADGAR M, NEKOEINIA M, ABASI H
  • 作者关键词:   riluzole, graphene quantum dot, electropolymerization, electrocatalysi, modified electrode
  • 出版物名称:   BULLETIN OF MATERIALS SCIENCE
  • ISSN:   0250-4707 EI 0973-7669
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1007/s12034-022-02699-0
  • 出版年:   2022

▎ 摘  要

Riluzole is a benzothiazole derivative that has neuroprotective properties. In this work, to measure riluzole, a glassy carbon electrode was modified by graphene quantum dots and polymerization of a synthesized monomer (4-(1H-benzimidazole-2-yl)benzene-1,2-diol). Characteristics and morphology of the modified electrode were studied using scanning electron microscopy and Fourier transform infrared. Investigation of the electrochemical behaviour of riluzole on the electrode revealed the electrocatalytic effect of the modified electrode. The repeatability (RSD = 3.7%, n = 7), reproducibility (RSD = 4.2%, n = 4) and long-term stability (RSD = 5.3%, 30 days) of the modified electrode have been studied. The calibration curve was linear in the concentration range of 0.8 to 50 mu mol l(-1) riluzole and the limit of detection was found to be 0.1 mu mol l(-1) riluzole. The proposed method has been successfully applied to determine the riluzole in human blood serum samples.