• 文献标题:   Graphene oxide-chitosan bionanocomposite: a highly efficient nanocatalyst for the one-pot three-component synthesis of trisubstituted imidazoles under solvent-free conditions
  • 文献类型:   Article
  • 作  者:   MALEKI A, PAYDAR R
  • 作者关键词:  
  • 出版物名称:   RSC ADVANCES
  • ISSN:   2046-2069
  • 通讯作者地址:   Iran Univ Sci Technol
  • 被引频次:   69
  • DOI:   10.1039/c5ra03355a
  • 出版年:   2015

▎ 摘  要

In the present work, a green, rapid, convenient and eco-friendly method for the synthesis of 2,4,5-trisubstituted imidazoles is described. In this method, we used 1,2-diketone or a-hydroxy ketone, an aldehyde and ammonium acetate in the presence of graphene oxide-chitosan bionanocomposite, which acted as an efficient nanocatalyst. This protocol has many advantages such as short reaction time, high yield, easy separation of the catalyst and solvent-free condition. We used differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and atomic force microscopy (AFM) to confirm that the nanocomposite was formed, and FT-IR, H-1 and C-13 NMR analyses were performed for the confirmation of the synthesized products.