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  • 文献标题:   Quencher-free molecular beacon: Enhancement of the signal-to-background ratio with graphene oxide
  • 文献类型:   Article
  • 作　　者:   YI JW, PARK J, SINGH NJ, LEE IJ, KIM KS, KIM BH
  • 作者关键词:   quencherfree molecular beacon, molecular beacon, graphene oxide, signaltobackground ratio, fluorescence
  • 出版物名称:   BIOORGANIC MEDICINAL CHEMISTRY LETTERS
  • ISSN:   0960-894X EI 1464-3405
  • 通讯作者地址:   Pohang Univ Sci Technol
  • 被引频次:   24
  • DOI:   10.1016/j.bmcl.2010.12.004
  • 出版年:   2011

▎ 摘　　要

We report the highly improved version of quencher-free molecular beacon (QF-MB) system by using graphene oxide (GO) as an external quencher. This QF-MB/GO system provided a higher S/B ratio (31,0) relative to that (2,2) of the same system in the absence of GO, while retaining a high selectivity for fully matched over single-base-mismatched targets. (C) 2010 Elsevier Ltd. All rights reserved.