▎ 摘　　要

Three-dimensional (3D) porous laser-scribed graphene (LSG) is a potential electrode material for flexible elec-trochemical sensors due to its high efficiency and low cost. However, the growth of nanoparticles usually de-pends on reducers or harsh conditions, which limit the application of flexible biosensors. To resolve this issue, 2D MXene nanosheets were applied to functionalize 3D LSG sheets with a C-O-Ti covalent crosslink and obtain an LSG-MXene hybrid scaffold. The shape-controlled Au-Pd bimetallic nanoparticles were synthesized on the surface of LSG-MXene by a self-reduction process at room temperature for 6 min to enhance its catalytic performance. As a proof of concept, the obtained hybrid nanocomposite was used to assess ascorbic acid (AA, 10-1600 mu M), dopamine (DA, 12-240 mu M), and uric acid (UA, 8-100, 200-800 mu M). The fabricated sensor exhibited a low detection limit (S/N = 3) of 3 mu M AA, 0.13 mu M DA, and 1.47 mu M UA. Furthermore, the Au-Pd/MXene/LSG was successfully applied to determine AA, DA, and UA in urine samples. Predictably, these outstanding performance sensors have great potential in flexible and wearable electronics.