• 文献标题:   Preparation and characterization of oxidized pectin/N-succinyl chitosan/graphene oxide hydrogels
  • 文献类型:   Article
  • 作  者:   BAZGHALEH AA, DOGOLSAR MA, BARZIN J
  • 作者关键词:   schiffbased reaction, hydrogen bond, selfhealing, injectability
  • 出版物名称:   CELLULOSE
  • ISSN:   0969-0239 EI 1572-882X
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1007/s10570-022-05015-5 EA DEC 2022
  • 出版年:   2023

▎ 摘  要

Oxidized pectin/N-succinyl chitosan (OP/NSC) hydrogel containing graphene oxide (GO) was developed as a self-healing, injectable and conductive hydrogel. The OP/NSC/GO hydrogel showed rapid gelation and excellent injectability due to the hydrogen bonding between GO nanosheets and NSC and OP macromolecules and Schiff-based crosslinking by amino and aldehyde functional groups of polysaccharide derivatives. The hydrogel had the best overall performance when the GO content was adjusted to 6 (mg/mL). The healing and gelation time of the hydrogel was 10 min and 13 s, respectively. The hydrogel also showed adequate swelling ability, appropriate conductivity, and good mechanical characteristics. Hemolysis tests indicated that all prepared hydrogels were non-hemolytic materials. In addition, GOs-loaded hydrogels showed low toxicity to fibroblast cells (L929), thus indicating good biocompatibility. These findings demonstrated the hydrogel's potential as a conductive, injectable, self-healing hydrogel for biomedical applications, particularly in tissue engineering.