1. 平台首页
  2. 国际论文信息
  • 文献标题:   Effect of magnetic graphene oxide on cellular behaviors and osteogenesis under a moderate static magnetic field
  • 文献类型:   Article
  • 作　　者:   HE Y, CHEN GH, LI Y, LI YM, YI C, ZHANG XL, LI HY, ZENG BH, WANG C, XIE WH, ZHAO W, YU DS
  • 作者关键词:   osteogenesi, magnetic graphene oxide, bmsc, static magnetic field, wnt/betacateninabbreviations: mgo, magnetic graphene oxide, smf static magnetic field, bmsc bone mesenchymal stem cell, te tissue engineering, go graphene oxide, ionps iron oxide nanoparticle, fda food drug administration, dpscs dental pulp stem cell, mapk mitogenactivated protein kinase, bte bone tissue engineering, bmp2 bone morphogenetic protein 2, dkk1 dickkopf1, oim osteogenicinducing medium, tem transmission electron microscopy, eds energy dispersive spectrometry, ftir fourier transform infrared spectroscopy, vsm vibrating sample magnetometer, dapi 4 6diamidino2phenylindole, clsm confocal laser scanning microscopy, cck8 cell counting kit8 test, od optical density, gapdh reduced glyceraldehydephosphate dehydrogenase, pvdf polyvinylidene fluoride, ecl electrochemiluminescence substrate, runx2 runtrelated transcription factor 2, gsk3 beta glycogen synthase kinase 3 beta, pgsk3 beta phosphorylation glycogen synthase kinase 3 beta, anova oneway analysis of variance, opn osteopontin, apc adenomatous polyposis coli
  • 出版物名称:   NANOMEDICINENANOTECHNOLOGY BIOLOGY MEDICINE
  • ISSN:   1549-9634 EI 1549-9642
  • 通讯作者地址:  
  • 被引频次:   5
  • DOI:   10.1016/j.nano.2021.102435 EA JUL 2021
  • 出版年:   2021

▎ 摘　　要

The biological behaviors of magnetic graphene oxide (MGO) in a static magnetic field (SMF) are unknown. The current study is to investigate the cellular behaviors, osteogenesis and the mechanism in BMSCs treated with MGO combined with an SMF. Results showed that the synthetic MGO particles were bio-compatible and could significantly improve the osteogenesis of BMSCs under SMFs, as verified by elevated alkaline phosphatase activity, mineralized nodule formation, and expressions of mRNA and protein levels. Under SMF at the same intensity, the addition of graphene oxide to Fe3O4 could increase the osteogenic ability of BMSCs. The Wnt/beta-catenin pathway was indicated to be related to the MGO-driven osteogenic behavior of the BMSCs under SMF. Taken together, our findings suggested that MGO under an SMF could promote osteogenesis in BMSCs through the Wnt/beta-catenin pathway and hence should attract more attention for practical applications in bone tissue regeneration. (C) 2021 The Author(s). Published by Elsevier Inc.