▎ 摘　　要

In cancer treatment, it still is a curial challenge to enhance therapeutic efficacy and reduce side effects. A novel reduced graphene oxide-based nanoplatform (rGO/PDex) has been constructed to deliver an anticancer drug, bortezomib (BTZ), for photo-chemotherapy. The structure and properties of the nanoplatform were characterized. The obtained data strongly indicated that rGO/PDex had enhanced stability. Further, folic acid was introduced and the resulting rGO/PDexF nanoplatform exhibited improved cellular uptake due to the active targeting effect. The anticancer drug BTZ could be effectively encapsulated into the rGO-based nanoplatform and be released in a controlled manner. In vitro experiments demonstrated that BTZ-loaded rGO-based nanoparticles displayed enhanced therapeutic efficacy compared with the single chemotherapy, indicating the great potential of rGO-based nanoparticles for cancer treatments. (c) 2018 Society of Chemical Industry