▎ 摘　　要

Uncontrolled massive bleeding remains a global issue, which requires an exigent response for safe and efficient hemostat. However, most of hemostats without antimicrobial property could trigger serious bacterial infection problem. Herein, a composite cryogel was synthesized by double bond N-dodecylated chitosan (DCSG) and graphene oxide (GO). The cryogel (DCSG/GO) with macroporous structure exhibited high-fluid adsorption ability, excellent mechanical property, and fluid-triggered shape recovery performance. Moreover, the in vitro blood coagulation experiments proved that DCSG/GO(5%) possessed better coagulation efficiency than medical gelatin sponge. And the DCSG/GO(5%) cryogel exhibited more erythrocyte and platelets activation. Besides, the cryogel had excellent near-infrared (NIR)-assisted photothermal antibacterial activity against both Escherichia coli and Staphylococcus aureus and killed 99% of them after 20 min NIR irradiation. In addition, the vitro hemolysis and cytotoxicity results proved the well biocompatibility of cryogel. Therefore, the biocompatible DCSG/GO cryogel has great potential application prospect in clinical hemorrhage control and anti-infection treatment.