▎ 摘　　要

Exceptional sensitivity and user-friendly operation of electrochemical sensors have made them a potential promise in diagnosing, monitoring, and treating Phenylketonuria (PKU). A three-dimensional graphene matrix decorated with cerium and copper oxide particles was synthesized by a one-pot hydrothermal technique. Because of several functional groups and active sites on the graphene composite, the fabricated sensor is able to detect PKU based on the non-enzymatic sensing strategy. The bimetallic composite with excellent electrocatalyst activity accelerates the electrooxidation of phenylalanine. The as-fabricated enzyme-free sensor exhibited a wide linearity toward concentration of L-phenylalanine (L-Phe), from 50 to 8000 mu m with R-2=0.9935 and a detection limit of 12 mu m (S/N=3). The experiments have been completed towards determining the L-Phe concentrations in human serum with the recovery of 96 % and 105 %.